Circadian Rhythms in Mammals: From Molecules to Behavior
A comprehensive overview of how peripheral and central oscillators synchronize to drive daily physiological cycles, covering CLOCK, BMAL1, PER, and CRY gene interactions.
🧬
💊
Chronotherapy: Optimizing Drug Administration to Biological Clocks
How aligning medication schedules with circadian pharmacokinetics and pharmacodynamics improves efficacy and reduces toxicity in oncology, cardiology, and immunology.
🌿
Plant Photoperiodism and the Phytochrome System
Exploring how plants measure day length to trigger flowering, dormancy, and growth cycles, with insights into cryptochrome and phytochrome signaling pathways.
✈️
Jet Lag, Shift Work, and Circadian Misalignment Disorders
The physiological and cognitive consequences of desynchronizing the master clock, including metabolic syndrome, sleep architecture disruption, and evidence-based realignment strategies.
🦀
Tidal and Lunar Rhythms in Marine Invertebrates
How intertidal organisms and deep-sea species entrain to lunar cycles and tidal forces, featuring the famous Goniatus eye movement model and cryptochronometer research.
🧠
The Suprachiasmatic Nucleus: Master Pacemaker of the Mammalian Brain
Anatomical, cellular, and circuit-level analysis of the SCN's role in entraining peripheral oscillators via neural and humoral outputs, including light-input pathways.