GABA is the principal inhibitory neurotransmitter in the mature vertebrate central nervous system. Explore peer-reviewed articles on GABAergic pathways, clinical applications, receptor pharmacology, and its role in neurology, psychiatry, and cognitive science.
A comprehensive review of ionotropic (GABA_A) and metabotropic (GABA_B) receptor subtypes, their molecular architecture, and their role in shaping cortical excitability and neural network oscillations.
Examining the clinical evidence linking GABAergic dysfunction to generalized anxiety disorder, panic attacks, and insomnia. Covers current pharmacological interventions and emerging non-pharmacological therapies.
Do over-the-counter GABA supplements cross the blood-brain barrier? This meta-analysis evaluates bioavailability, therapeutic efficacy, and safety profiles based on 42 randomized controlled trials.
Contrary to its mature inhibitory function, GABA acts as an excitatory trophic factor in the developing brain. Explores GABA's role in neuronal migration, dendritic arborization, and critical period plasticity.
Beyond benzodiazepines and barbiturates: exploring positive allosteric modulators, subtype-selective ligands, and neurosteroid-based therapies with improved safety and reduced tolerance profiles.
How impaired GABA synthesis, uptake, and receptor trafficking contribute to hyperexcitability. Reviews current antiepileptic drug mechanisms and novel gene-therapy approaches targeting GAD65 and GAT-1.