AZ-CT-2024-114 | NCT06182944

Phase II Evaluation of ZN-789 in Metastatic NSCLC Patients

Phase II Recruiting Oncology

Multicenter, randomized, double-blind trial assessing efficacy and safety of oral ZN-789 monotherapy versus standard chemotherapy in stage IV non-small cell lung cancer.

๐Ÿ“ 14 Countries ๐Ÿ‘ฅ 412 / 600 Enrolled
View Protocol Details โ†’
AZ-CT-2023-089 | NCT05921102

Phase III Safety & Efficacy of AZ-Neuro4 in Early-Stage Alzheimer's

Phase III Active Neurology

Global Phase III program evaluating cognitive preservation and biomarker modulation in mild-to-moderate Alzheimer's disease over a 18-month treatment period.

๐Ÿ“ 22 Countries ๐Ÿ‘ฅ 1,840 / 2,500 Enrolled
View Protocol Details โ†’
AZ-CT-2024-201 | NCT06442811

First-in-Human Dose Escalation of ZN-ImmuX Biologics

Phase I Recruiting Immunology

Open-label, dose-escalation study to determine maximum tolerated dose, pharmacokinetics, and preliminary anti-inflammatory activity in healthy volunteers and RA patients.

๐Ÿ“ 5 Countries ๐Ÿ‘ฅ 48 / 120 Enrolled
View Protocol Details โ†’
AZ-CT-2023-156 | NCT05889432

CardioGuardโ„ข Phase III Outcomes in Post-MI Patients

Phase III Recruiting Cardiology

Event-driven trial assessing reduction in major adverse cardiovascular events (MACE) with novel lipid-modulating therapy following acute myocardial infarction.

๐Ÿ“ 18 Countries ๐Ÿ‘ฅ 3,210 / 5,000 Enrolled
View Protocol Details โ†’
AZ-CT-2021-042 | NCT04812399

Post-Marketing Surveillance of ZN-Tarcevaยฎ in GI Cancers

Phase IV Completed Oncology

Real-world evidence study tracking long-term safety, treatment adherence, and quality-of-life metrics across 900+ sites following FDA approval.

๐Ÿ“ 31 Countries ๐Ÿ‘ฅ 8,450 / 8,500 Enrolled
View Published Results โ†’
AZ-CT-2024-178 | NCT06311045

ZenthaSynโ„ข Digital Therapeutic for Treatment-Resistant Depression

Phase II Active Neurology

Randomized controlled trial evaluating AI-driven neurofeedback and CBT integration in adults with TRD, measuring PHQ-9 scores and neural connectivity markers.

๐Ÿ“ 8 Countries ๐Ÿ‘ฅ 290 / 400 Enrolled
View Protocol Details โ†’

Pipeline Overview

Phase I

14

Safety & Dosing

Phase II

23

Efficacy & Biomarkers

Phase III

18

Global Multicenter

Phase IV

9

Real-World Evidence

Completed

67

Published Results

Active Sites

1,240+

Across 58 Nations

Ethics, Safety & Regulatory Compliance

Every Zenth Health Sciences trial adheres to ICH-GCP guidelines, FDA/EMA regulations, and WHO standards. Our Independent Ethics Committees (IECs) and Data Safety Monitoring Boards (DSMBs) operate autonomously to ensure patient welfare remains the highest priority. All protocols are registered publicly on ClinicalTrials.gov and EU Clinical Trials Register.

โœ“ ICH-GCP Compliant
โœ“ FDA/EMA Aligned
โœ“ IRB/IEC Approved
โœ“ GDPR/HIPAA Secured
โœ“ DSMB Monitored
โœ“ Transparent Reporting
Adverse Event Reporting Rate 100% Transparent
Protocol Deviation Rate < 2.1%
Patient Retention 94.3%
Regulatory Audits Passed 100% (Last 36 Months)

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