Neurosteroids
Neurosteroids are steroid hormones synthesized directly within the central and peripheral nervous systems. They modulate neural excitability, promote neurogenesis, and play critical roles in neuroprotection, stress response, and psychiatric regulation.
Allopregnanolone: Mechanisms of Action at GABA-A Receptors
Examining the potent positive allosteric modulation of allopregnanolone on α4βδ GABA-A subtypes, and its implications for treatment-resistant depression and postpartum mood disorders.
DHEA-S and Age-Related Cognitive Decline
A longitudinal analysis of dehydroepiandrosterone sulfate levels in aging populations, correlating serum concentrations with hippocampal volume and episodic memory retention.
Inner Cellular Neurosteroid Synthesis Pathways
How neurons and glial cells independently synthesize steroids from cholesterol via the inner cellular pathway, bypassing adrenal and gonadal precursors entirely.
Neuroprotective Effects in Ischemic Stroke Models
Evaluating the anti-apoptotic and anti-inflammatory properties of endogenous neurosteroids following cerebral ischemia, with focus on 3α-hydroxy-5α-pregnan-20-one.
Catamenial Epilepsy and Neuroactive Steroid Fluctuations
Understanding the interplay between progesterone withdrawal, allopregnanolone depletion, and seizure exacerbation in catamenial epilepsy syndromes.
Next-Generation Neurosteroid Drug Candidates
A pipeline analysis of selective neuroactive steroid modulators (NASMs) currently in Phase II/III trials for PTSD, anxiety, and neurodegenerative diseases.